Clot Treatment via Spinning-Induced Fibrin Microstructure Densification and Clot Volume Reduction
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To uncover the underlying mechanisms and optimize performance, we combine in vitro experiments with dissipative particle dynamics (DPD) simulations for multiscale analysis of clot volume reduction and microstructural densification under integrated compression and shear. Experiments quantify macroscopic clot volume reduction under controlled loading, while simulations reveal microscale fibrin network densification and RBC release. This systematic study provides a quantitative understanding of how different loading modes alter clot microstructure across clot types.